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  • Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err on the side of caution and allow FDA do its job and demand some study be done so that the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on his or her medications. Researchers discovered that participants taking this drug for any year, dropped excess weight within 4 weeks and have kept the load off throughout the 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of many active ingredient, which may make them more effective and safer. Combo-pilling will be the newest fad or also the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that by right now there are no long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not be used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. Other people who must avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave mustn't be prescribed for women who are pregnant or wanting to become pregnant.


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